Regulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition

Regulatory T (Treg) cells can induce senescence of tumour-associated effector T cells, but it is not clear how. Here the authors show that Treg cells outcompete effector T cells for glucose uptake, resulting in activation of the DNA damage response in effector T cells.

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Autores principales: Xia Liu, Wei Mo, Jian Ye, Lingyun Li, Yanping Zhang, Eddy C. Hsueh, Daniel F. Hoft, Guangyong Peng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/8b3bbe54a08b4d00adeca8ec2f0f310b
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