Regulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition

Regulatory T (Treg) cells can induce senescence of tumour-associated effector T cells, but it is not clear how. Here the authors show that Treg cells outcompete effector T cells for glucose uptake, resulting in activation of the DNA damage response in effector T cells.

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Autores principales:	Xia Liu, Wei Mo, Jian Ye, Lingyun Li, Yanping Zhang, Eddy C. Hsueh, Daniel F. Hoft, Guangyong Peng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8b3bbe54a08b4d00adeca8ec2f0f310b
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spelling	oai:doaj.org-article:8b3bbe54a08b4d00adeca8ec2f0f310b2021-12-02T15:33:41ZRegulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition10.1038/s41467-017-02689-52041-1723https://doaj.org/article/8b3bbe54a08b4d00adeca8ec2f0f310b2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02689-5https://doaj.org/toc/2041-1723Regulatory T (Treg) cells can induce senescence of tumour-associated effector T cells, but it is not clear how. Here the authors show that Treg cells outcompete effector T cells for glucose uptake, resulting in activation of the DNA damage response in effector T cells.Xia LiuWei MoJian YeLingyun LiYanping ZhangEddy C. HsuehDaniel F. HoftGuangyong PengNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xia Liu Wei Mo Jian Ye Lingyun Li Yanping Zhang Eddy C. Hsueh Daniel F. Hoft Guangyong Peng Regulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition
description	Regulatory T (Treg) cells can induce senescence of tumour-associated effector T cells, but it is not clear how. Here the authors show that Treg cells outcompete effector T cells for glucose uptake, resulting in activation of the DNA damage response in effector T cells.
format	article
author	Xia Liu Wei Mo Jian Ye Lingyun Li Yanping Zhang Eddy C. Hsueh Daniel F. Hoft Guangyong Peng
author_facet	Xia Liu Wei Mo Jian Ye Lingyun Li Yanping Zhang Eddy C. Hsueh Daniel F. Hoft Guangyong Peng
author_sort	Xia Liu
title	Regulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition
title_short	Regulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition
title_full	Regulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition
title_fullStr	Regulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition
title_full_unstemmed	Regulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition
title_sort	regulatory t cells trigger effector t cell dna damage and senescence caused by metabolic competition
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8b3bbe54a08b4d00adeca8ec2f0f310b
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Regulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition

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