Efficient modification of λ-DNA substrates for single-molecule studies

Abstract Single-molecule studies of protein-nucleic acid interactions frequently require site-specific modification of long DNA substrates. The bacteriophage λ is a convenient source of high quality long (48.5 kb) DNA. However, introducing specific sequences, tertiary structures, and chemical modifi...

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Autores principales: Yoori Kim, Armando de la Torre, Andrew A. Leal, Ilya J. Finkelstein
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/8b70cb40cf1a47ca9a485db753930e3d
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