Highly selective nickel-catalyzed gem-difluoropropargylation of unactivated alkylzinc reagents

Difluoroalkylated compounds find wide application in medicinal chemistry. Here, the authors describe the mild nickel-catalyzed difluoroalkylation of aliphatic alkylzinc reagents with gem-difluoropropargylbromides and show its utility in a number of post-synthetic transformations.

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Detalles Bibliográficos
Autores principales:	Lun An, Chang Xu, Xingang Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8baa04f025c24df1820a6e3364a04101
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spelling	oai:doaj.org-article:8baa04f025c24df1820a6e3364a041012021-12-02T15:38:39ZHighly selective nickel-catalyzed gem-difluoropropargylation of unactivated alkylzinc reagents10.1038/s41467-017-01540-12041-1723https://doaj.org/article/8baa04f025c24df1820a6e3364a041012017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01540-1https://doaj.org/toc/2041-1723Difluoroalkylated compounds find wide application in medicinal chemistry. Here, the authors describe the mild nickel-catalyzed difluoroalkylation of aliphatic alkylzinc reagents with gem-difluoropropargylbromides and show its utility in a number of post-synthetic transformations.Lun AnChang XuXingang ZhangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lun An Chang Xu Xingang Zhang Highly selective nickel-catalyzed gem-difluoropropargylation of unactivated alkylzinc reagents
description	Difluoroalkylated compounds find wide application in medicinal chemistry. Here, the authors describe the mild nickel-catalyzed difluoroalkylation of aliphatic alkylzinc reagents with gem-difluoropropargylbromides and show its utility in a number of post-synthetic transformations.
format	article
author	Lun An Chang Xu Xingang Zhang
author_facet	Lun An Chang Xu Xingang Zhang
author_sort	Lun An
title	Highly selective nickel-catalyzed gem-difluoropropargylation of unactivated alkylzinc reagents
title_short	Highly selective nickel-catalyzed gem-difluoropropargylation of unactivated alkylzinc reagents
title_full	Highly selective nickel-catalyzed gem-difluoropropargylation of unactivated alkylzinc reagents
title_fullStr	Highly selective nickel-catalyzed gem-difluoropropargylation of unactivated alkylzinc reagents
title_full_unstemmed	Highly selective nickel-catalyzed gem-difluoropropargylation of unactivated alkylzinc reagents
title_sort	highly selective nickel-catalyzed gem-difluoropropargylation of unactivated alkylzinc reagents
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8baa04f025c24df1820a6e3364a04101
work_keys_str_mv	AT lunan highlyselectivenickelcatalyzedgemdifluoropropargylationofunactivatedalkylzincreagents AT changxu highlyselectivenickelcatalyzedgemdifluoropropargylationofunactivatedalkylzincreagents AT xingangzhang highlyselectivenickelcatalyzedgemdifluoropropargylationofunactivatedalkylzincreagents
_version_	1718386125196754944

Highly selective nickel-catalyzed gem-difluoropropargylation of unactivated alkylzinc reagents

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