Global H3.3 dynamic deposition defines its bimodal role in cell fate transition

Histone variant H3.3 is incorporated at transcriptionally active genes and is associated with active marks. Here, the authors investigate H3.3 deposition during reprogramming and find that initially H3.3 helps maintain parental cell fate and is later required for establishment of the cell lineages.

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Autores principales: Hai-Tong Fang, Chadi A. EL Farran, Qiao Rui Xing, Li-Feng Zhang, Hu Li, Bing Lim, Yuin-Han Loh
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/8bb5a312a8fb4f8abc29d97efc7188ac
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