Global H3.3 dynamic deposition defines its bimodal role in cell fate transition

Histone variant H3.3 is incorporated at transcriptionally active genes and is associated with active marks. Here, the authors investigate H3.3 deposition during reprogramming and find that initially H3.3 helps maintain parental cell fate and is later required for establishment of the cell lineages.

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Autores principales:	Hai-Tong Fang, Chadi A. EL Farran, Qiao Rui Xing, Li-Feng Zhang, Hu Li, Bing Lim, Yuin-Han Loh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8bb5a312a8fb4f8abc29d97efc7188ac
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spelling	oai:doaj.org-article:8bb5a312a8fb4f8abc29d97efc7188ac2021-12-02T17:32:33ZGlobal H3.3 dynamic deposition defines its bimodal role in cell fate transition10.1038/s41467-018-03904-72041-1723https://doaj.org/article/8bb5a312a8fb4f8abc29d97efc7188ac2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03904-7https://doaj.org/toc/2041-1723Histone variant H3.3 is incorporated at transcriptionally active genes and is associated with active marks. Here, the authors investigate H3.3 deposition during reprogramming and find that initially H3.3 helps maintain parental cell fate and is later required for establishment of the cell lineages.Hai-Tong FangChadi A. EL FarranQiao Rui XingLi-Feng ZhangHu LiBing LimYuin-Han LohNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hai-Tong Fang Chadi A. EL Farran Qiao Rui Xing Li-Feng Zhang Hu Li Bing Lim Yuin-Han Loh Global H3.3 dynamic deposition defines its bimodal role in cell fate transition
description	Histone variant H3.3 is incorporated at transcriptionally active genes and is associated with active marks. Here, the authors investigate H3.3 deposition during reprogramming and find that initially H3.3 helps maintain parental cell fate and is later required for establishment of the cell lineages.
format	article
author	Hai-Tong Fang Chadi A. EL Farran Qiao Rui Xing Li-Feng Zhang Hu Li Bing Lim Yuin-Han Loh
author_facet	Hai-Tong Fang Chadi A. EL Farran Qiao Rui Xing Li-Feng Zhang Hu Li Bing Lim Yuin-Han Loh
author_sort	Hai-Tong Fang
title	Global H3.3 dynamic deposition defines its bimodal role in cell fate transition
title_short	Global H3.3 dynamic deposition defines its bimodal role in cell fate transition
title_full	Global H3.3 dynamic deposition defines its bimodal role in cell fate transition
title_fullStr	Global H3.3 dynamic deposition defines its bimodal role in cell fate transition
title_full_unstemmed	Global H3.3 dynamic deposition defines its bimodal role in cell fate transition
title_sort	global h3.3 dynamic deposition defines its bimodal role in cell fate transition
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8bb5a312a8fb4f8abc29d97efc7188ac
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Global H3.3 dynamic deposition defines its bimodal role in cell fate transition

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