A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis

A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis

RNF43 is frequently mutated in cancers and negatively regulates Wnt signalling. Here, the authors report that RNF43 phosphorylation at a serine triplet is required for the negative regulation of Wnt signalling and that the phosphorylation of RNF43 suppresses cancer-associated oncogenic RNF43 mutants...

Full description

Saved in:
Bibliographic Details
Main Authors: Tadasuke Tsukiyama, Juqi Zou, Jihoon Kim, Shohei Ogamino, Yuki Shino, Takamasa Masuda, Alessandra Merenda, Masaki Matsumoto, Yoichiro Fujioka, Tomonori Hirose, Sayuri Terai, Hidehisa Takahashi, Tohru Ishitani, Keiichi I. Nakayama, Yusuke Ohba, Bon-Kyoung Koo, Shigetsugu Hatakeyama
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Science
Q
Online Access:https://doaj.org/article/8bbcf86e1ff943ee8f363d3d01a94e7d
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/8bbcf86e1ff943ee8f363d3d01a94e7d

Similar Items