A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis

RNF43 is frequently mutated in cancers and negatively regulates Wnt signalling. Here, the authors report that RNF43 phosphorylation at a serine triplet is required for the negative regulation of Wnt signalling and that the phosphorylation of RNF43 suppresses cancer-associated oncogenic RNF43 mutants...

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Autores principales:	Tadasuke Tsukiyama, Juqi Zou, Jihoon Kim, Shohei Ogamino, Yuki Shino, Takamasa Masuda, Alessandra Merenda, Masaki Matsumoto, Yoichiro Fujioka, Tomonori Hirose, Sayuri Terai, Hidehisa Takahashi, Tohru Ishitani, Keiichi I. Nakayama, Yusuke Ohba, Bon-Kyoung Koo, Shigetsugu Hatakeyama
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8bbcf86e1ff943ee8f363d3d01a94e7d
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spelling	oai:doaj.org-article:8bbcf86e1ff943ee8f363d3d01a94e7d2021-12-02T18:50:53ZA phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis10.1038/s41467-020-18257-32041-1723https://doaj.org/article/8bbcf86e1ff943ee8f363d3d01a94e7d2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18257-3https://doaj.org/toc/2041-1723RNF43 is frequently mutated in cancers and negatively regulates Wnt signalling. Here, the authors report that RNF43 phosphorylation at a serine triplet is required for the negative regulation of Wnt signalling and that the phosphorylation of RNF43 suppresses cancer-associated oncogenic RNF43 mutants.Tadasuke TsukiyamaJuqi ZouJihoon KimShohei OgaminoYuki ShinoTakamasa MasudaAlessandra MerendaMasaki MatsumotoYoichiro FujiokaTomonori HiroseSayuri TeraiHidehisa TakahashiTohru IshitaniKeiichi I. NakayamaYusuke OhbaBon-Kyoung KooShigetsugu HatakeyamaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tadasuke Tsukiyama Juqi Zou Jihoon Kim Shohei Ogamino Yuki Shino Takamasa Masuda Alessandra Merenda Masaki Matsumoto Yoichiro Fujioka Tomonori Hirose Sayuri Terai Hidehisa Takahashi Tohru Ishitani Keiichi I. Nakayama Yusuke Ohba Bon-Kyoung Koo Shigetsugu Hatakeyama A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis
description	RNF43 is frequently mutated in cancers and negatively regulates Wnt signalling. Here, the authors report that RNF43 phosphorylation at a serine triplet is required for the negative regulation of Wnt signalling and that the phosphorylation of RNF43 suppresses cancer-associated oncogenic RNF43 mutants.
format	article
author	Tadasuke Tsukiyama Juqi Zou Jihoon Kim Shohei Ogamino Yuki Shino Takamasa Masuda Alessandra Merenda Masaki Matsumoto Yoichiro Fujioka Tomonori Hirose Sayuri Terai Hidehisa Takahashi Tohru Ishitani Keiichi I. Nakayama Yusuke Ohba Bon-Kyoung Koo Shigetsugu Hatakeyama
author_facet	Tadasuke Tsukiyama Juqi Zou Jihoon Kim Shohei Ogamino Yuki Shino Takamasa Masuda Alessandra Merenda Masaki Matsumoto Yoichiro Fujioka Tomonori Hirose Sayuri Terai Hidehisa Takahashi Tohru Ishitani Keiichi I. Nakayama Yusuke Ohba Bon-Kyoung Koo Shigetsugu Hatakeyama
author_sort	Tadasuke Tsukiyama
title	A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis
title_short	A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis
title_full	A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis
title_fullStr	A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis
title_full_unstemmed	A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis
title_sort	phospho-switch controls rnf43-mediated degradation of wnt receptors to suppress tumorigenesis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8bbcf86e1ff943ee8f363d3d01a94e7d
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A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis

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