Extensive Gene Amplification as a Mechanism for Piperacillin-Tazobactam Resistance in <named-content content-type="genus-species">Escherichia coli</named-content>

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Extensive Gene Amplification as a Mechanism for Piperacillin-Tazobactam Resistance in <named-content content-type="genus-species">Escherichia coli</named-content>

ABSTRACT Although the TEM-1 β-lactamase (BlaTEM-1) hydrolyzes penicillins and narrow-spectrum cephalosporins, organisms expressing this enzyme are typically susceptible to β-lactam/β-lactamase inhibitor combinations such as piperacillin-tazobactam (TZP). However, our previous work led to the discove...

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Auteurs principaux:	Lisa M. Schechter, David P. Creely, Cherilyn D. Garner, Dee Shortridge, Hoan Nguyen, Lei Chen, Blake M. Hanson, Erica Sodergren, George M. Weinstock, W. Michael Dunne, Alex van Belkum, Shana R. Leopold
Format:	article
Langue:	EN
Publié:	American Society for Microbiology 2018
Sujets:	Escherichia coli TEM-1 antibiotic resistance gene amplification piperacillin-tazobactam Microbiology QR1-502
Accès en ligne:	https://doaj.org/article/8bc875ddf68a47e3b51e256a2aab5b35
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