Biased activation of β2-AR/Gi/GRK2 signal pathway attenuated β1-AR sustained activation induced by β1-adrenergic receptor autoantibody
Abstract Heart failure is the terminal stage of many cardiac diseases, in which β1-adrenoceptor (β1-AR) autoantibody (β1-AA) has a causative role. By continuously activating β1-AR, β1-AA can induce cytotoxicity, leading to cardiomyocyte apoptosis and heart dysfunction. However, the mechanism underly...
Enregistré dans:
| Auteurs principaux: | , , , , , , , , |
|---|---|
| Format: | article |
| Langue: | EN |
| Publié: |
Nature Publishing Group
2021
|
| Sujets: | |
| Accès en ligne: | https://doaj.org/article/8bd0e293fbd745609331d73aadadb01c |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|