Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target

Metastatic dissemination contributes to the lethality in pancreatic ductal adenocarcinoma (PDAC). Here, the authors perform RNA-sequencing on patient derived circulating tumor cells (CTCs) and identify three major CTC subgroups, and show the therapeutic potential of targeting LIN28B/let-7 pathway to...

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Autores principales:	Joseph W. Franses, Julia Philipp, Pavlos Missios, Irun Bhan, Ann Liu, Chittampalli Yashaswini, Eric Tai, Huili Zhu, Matteo Ligorio, Benjamin Nicholson, Elizabeth M. Tassoni, Niyati Desai, Anupriya S. Kulkarni, Annamaria Szabolcs, Theodore S. Hong, Andrew S. Liss, Carlos Fernandez-del Castillo, David P. Ryan, Shyamala Maheswaran, Daniel A. Haber, George Q. Daley, David T. Ting
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8bd6be3bfdd24c5bb956606bf62f9ee0
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spelling	oai:doaj.org-article:8bd6be3bfdd24c5bb956606bf62f9ee02021-12-02T16:13:39ZPancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target10.1038/s41467-020-17150-32041-1723https://doaj.org/article/8bd6be3bfdd24c5bb956606bf62f9ee02020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17150-3https://doaj.org/toc/2041-1723Metastatic dissemination contributes to the lethality in pancreatic ductal adenocarcinoma (PDAC). Here, the authors perform RNA-sequencing on patient derived circulating tumor cells (CTCs) and identify three major CTC subgroups, and show the therapeutic potential of targeting LIN28B/let-7 pathway to halt cancer metastasis.Joseph W. FransesJulia PhilippPavlos MissiosIrun BhanAnn LiuChittampalli YashaswiniEric TaiHuili ZhuMatteo LigorioBenjamin NicholsonElizabeth M. TassoniNiyati DesaiAnupriya S. KulkarniAnnamaria SzabolcsTheodore S. HongAndrew S. LissCarlos Fernandez-del CastilloDavid P. RyanShyamala MaheswaranDaniel A. HaberGeorge Q. DaleyDavid T. TingNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joseph W. Franses Julia Philipp Pavlos Missios Irun Bhan Ann Liu Chittampalli Yashaswini Eric Tai Huili Zhu Matteo Ligorio Benjamin Nicholson Elizabeth M. Tassoni Niyati Desai Anupriya S. Kulkarni Annamaria Szabolcs Theodore S. Hong Andrew S. Liss Carlos Fernandez-del Castillo David P. Ryan Shyamala Maheswaran Daniel A. Haber George Q. Daley David T. Ting Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target
description	Metastatic dissemination contributes to the lethality in pancreatic ductal adenocarcinoma (PDAC). Here, the authors perform RNA-sequencing on patient derived circulating tumor cells (CTCs) and identify three major CTC subgroups, and show the therapeutic potential of targeting LIN28B/let-7 pathway to halt cancer metastasis.
format	article
author	Joseph W. Franses Julia Philipp Pavlos Missios Irun Bhan Ann Liu Chittampalli Yashaswini Eric Tai Huili Zhu Matteo Ligorio Benjamin Nicholson Elizabeth M. Tassoni Niyati Desai Anupriya S. Kulkarni Annamaria Szabolcs Theodore S. Hong Andrew S. Liss Carlos Fernandez-del Castillo David P. Ryan Shyamala Maheswaran Daniel A. Haber George Q. Daley David T. Ting
author_facet	Joseph W. Franses Julia Philipp Pavlos Missios Irun Bhan Ann Liu Chittampalli Yashaswini Eric Tai Huili Zhu Matteo Ligorio Benjamin Nicholson Elizabeth M. Tassoni Niyati Desai Anupriya S. Kulkarni Annamaria Szabolcs Theodore S. Hong Andrew S. Liss Carlos Fernandez-del Castillo David P. Ryan Shyamala Maheswaran Daniel A. Haber George Q. Daley David T. Ting
author_sort	Joseph W. Franses
title	Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target
title_short	Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target
title_full	Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target
title_fullStr	Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target
title_full_unstemmed	Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target
title_sort	pancreatic circulating tumor cell profiling identifies lin28b as a metastasis driver and drug target
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8bd6be3bfdd24c5bb956606bf62f9ee0
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Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target

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