SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance

SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance

SARS-CoV-2 infection damages the airways. Here the authors show that SARS-CoV-2 infection induces the rapid loss of airway motile cilia, resulting in altered cilia clearance function. Cilia loss is preceded by reduced expression of the ciliogenesis regulator Foxj1.

Saved in:
Bibliographic Details
Main Authors: Rémy Robinot, Mathieu Hubert, Guilherme Dias de Melo, Françoise Lazarini, Timothée Bruel, Nikaïa Smith, Sylvain Levallois, Florence Larrous, Julien Fernandes, Stacy Gellenoncourt, Stéphane Rigaud, Olivier Gorgette, Catherine Thouvenot, Céline Trébeau, Adeline Mallet, Guillaume Duménil, Samy Gobaa, Raphaël Etournay, Pierre-Marie Lledo, Marc Lecuit, Hervé Bourhy, Darragh Duffy, Vincent Michel, Olivier Schwartz, Lisa A. Chakrabarti
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
Q
Online Access:https://doaj.org/article/8bf151f6060345a3ae7b514eb9de5a9b
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/8bf151f6060345a3ae7b514eb9de5a9b

Similar Items