SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance
SARS-CoV-2 infection damages the airways. Here the authors show that SARS-CoV-2 infection induces the rapid loss of airway motile cilia, resulting in altered cilia clearance function. Cilia loss is preceded by reduced expression of the ciliogenesis regulator Foxj1.
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Nature Portfolio
2021
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oai:doaj.org-article:8bf151f6060345a3ae7b514eb9de5a9b2021-12-02T18:36:59ZSARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance10.1038/s41467-021-24521-x2041-1723https://doaj.org/article/8bf151f6060345a3ae7b514eb9de5a9b2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24521-xhttps://doaj.org/toc/2041-1723SARS-CoV-2 infection damages the airways. Here the authors show that SARS-CoV-2 infection induces the rapid loss of airway motile cilia, resulting in altered cilia clearance function. Cilia loss is preceded by reduced expression of the ciliogenesis regulator Foxj1.Rémy RobinotMathieu HubertGuilherme Dias de MeloFrançoise LazariniTimothée BruelNikaïa SmithSylvain LevalloisFlorence LarrousJulien FernandesStacy GellenoncourtStéphane RigaudOlivier GorgetteCatherine ThouvenotCéline TrébeauAdeline MalletGuillaume DuménilSamy GobaaRaphaël EtournayPierre-Marie LledoMarc LecuitHervé BourhyDarragh DuffyVincent MichelOlivier SchwartzLisa A. ChakrabartiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
| institution |
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DOAJ |
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EN |
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Science Q |
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Science Q Rémy Robinot Mathieu Hubert Guilherme Dias de Melo Françoise Lazarini Timothée Bruel Nikaïa Smith Sylvain Levallois Florence Larrous Julien Fernandes Stacy Gellenoncourt Stéphane Rigaud Olivier Gorgette Catherine Thouvenot Céline Trébeau Adeline Mallet Guillaume Duménil Samy Gobaa Raphaël Etournay Pierre-Marie Lledo Marc Lecuit Hervé Bourhy Darragh Duffy Vincent Michel Olivier Schwartz Lisa A. Chakrabarti SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance |
| description |
SARS-CoV-2 infection damages the airways. Here the authors show that SARS-CoV-2 infection induces the rapid loss of airway motile cilia, resulting in altered cilia clearance function. Cilia loss is preceded by reduced expression of the ciliogenesis regulator Foxj1. |
| format |
article |
| author |
Rémy Robinot Mathieu Hubert Guilherme Dias de Melo Françoise Lazarini Timothée Bruel Nikaïa Smith Sylvain Levallois Florence Larrous Julien Fernandes Stacy Gellenoncourt Stéphane Rigaud Olivier Gorgette Catherine Thouvenot Céline Trébeau Adeline Mallet Guillaume Duménil Samy Gobaa Raphaël Etournay Pierre-Marie Lledo Marc Lecuit Hervé Bourhy Darragh Duffy Vincent Michel Olivier Schwartz Lisa A. Chakrabarti |
| author_facet |
Rémy Robinot Mathieu Hubert Guilherme Dias de Melo Françoise Lazarini Timothée Bruel Nikaïa Smith Sylvain Levallois Florence Larrous Julien Fernandes Stacy Gellenoncourt Stéphane Rigaud Olivier Gorgette Catherine Thouvenot Céline Trébeau Adeline Mallet Guillaume Duménil Samy Gobaa Raphaël Etournay Pierre-Marie Lledo Marc Lecuit Hervé Bourhy Darragh Duffy Vincent Michel Olivier Schwartz Lisa A. Chakrabarti |
| author_sort |
Rémy Robinot |
| title |
SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance |
| title_short |
SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance |
| title_full |
SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance |
| title_fullStr |
SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance |
| title_full_unstemmed |
SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance |
| title_sort |
sars-cov-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/8bf151f6060345a3ae7b514eb9de5a9b |
| work_keys_str_mv |
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| _version_ |
1718377873492934656 |