Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors

Chromothripsis and chromoanasynthesis lead to locally clustered rearrangements affecting one or a few chromosomes, but their impact on cancer development and progression is unclear. Here the authors analyse the role of DNA repair factors in brain tumors by whole-genome sequencing of tumors from mous...

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Autores principales:	Manasi Ratnaparkhe, John K. L. Wong, Pei-Chi Wei, Mario Hlevnjak, Thorsten Kolb, Milena Simovic, Daniel Haag, Yashna Paul, Frauke Devens, Paul Northcott, David T. W. Jones, Marcel Kool, Anna Jauch, Agata Pastorczak, Wojciech Mlynarski, Andrey Korshunov, Rajiv Kumar, Susanna M. Downing, Stefan M. Pfister, Marc Zapatka, Peter J. McKinnon, Frederick W. Alt, Peter Lichter, Aurélie Ernst
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8c14a72fa08b47349febd37357e6a636
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spelling	oai:doaj.org-article:8c14a72fa08b47349febd37357e6a6362021-12-02T16:56:53ZDefective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors10.1038/s41467-018-06925-42041-1723https://doaj.org/article/8c14a72fa08b47349febd37357e6a6362018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06925-4https://doaj.org/toc/2041-1723Chromothripsis and chromoanasynthesis lead to locally clustered rearrangements affecting one or a few chromosomes, but their impact on cancer development and progression is unclear. Here the authors analyse the role of DNA repair factors in brain tumors by whole-genome sequencing of tumors from mouse models of medulloblastoma or high grade gliomas.Manasi RatnaparkheJohn K. L. WongPei-Chi WeiMario HlevnjakThorsten KolbMilena SimovicDaniel HaagYashna PaulFrauke DevensPaul NorthcottDavid T. W. JonesMarcel KoolAnna JauchAgata PastorczakWojciech MlynarskiAndrey KorshunovRajiv KumarSusanna M. DowningStefan M. PfisterMarc ZapatkaPeter J. McKinnonFrederick W. AltPeter LichterAurélie ErnstNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Manasi Ratnaparkhe John K. L. Wong Pei-Chi Wei Mario Hlevnjak Thorsten Kolb Milena Simovic Daniel Haag Yashna Paul Frauke Devens Paul Northcott David T. W. Jones Marcel Kool Anna Jauch Agata Pastorczak Wojciech Mlynarski Andrey Korshunov Rajiv Kumar Susanna M. Downing Stefan M. Pfister Marc Zapatka Peter J. McKinnon Frederick W. Alt Peter Lichter Aurélie Ernst Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors
description	Chromothripsis and chromoanasynthesis lead to locally clustered rearrangements affecting one or a few chromosomes, but their impact on cancer development and progression is unclear. Here the authors analyse the role of DNA repair factors in brain tumors by whole-genome sequencing of tumors from mouse models of medulloblastoma or high grade gliomas.
format	article
author	Manasi Ratnaparkhe John K. L. Wong Pei-Chi Wei Mario Hlevnjak Thorsten Kolb Milena Simovic Daniel Haag Yashna Paul Frauke Devens Paul Northcott David T. W. Jones Marcel Kool Anna Jauch Agata Pastorczak Wojciech Mlynarski Andrey Korshunov Rajiv Kumar Susanna M. Downing Stefan M. Pfister Marc Zapatka Peter J. McKinnon Frederick W. Alt Peter Lichter Aurélie Ernst
author_facet	Manasi Ratnaparkhe John K. L. Wong Pei-Chi Wei Mario Hlevnjak Thorsten Kolb Milena Simovic Daniel Haag Yashna Paul Frauke Devens Paul Northcott David T. W. Jones Marcel Kool Anna Jauch Agata Pastorczak Wojciech Mlynarski Andrey Korshunov Rajiv Kumar Susanna M. Downing Stefan M. Pfister Marc Zapatka Peter J. McKinnon Frederick W. Alt Peter Lichter Aurélie Ernst
author_sort	Manasi Ratnaparkhe
title	Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors
title_short	Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors
title_full	Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors
title_fullStr	Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors
title_full_unstemmed	Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors
title_sort	defective dna damage repair leads to frequent catastrophic genomic events in murine and human tumors
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8c14a72fa08b47349febd37357e6a636
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Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors

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