A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus

The coordination of interactions between multiple regulatory elements and genes within a chromatin domain remains poorly understood. Here, the authors use a method to detect multi-way chromatin interactions in a mouse model in which the α-globin domain is extended to include several additional genes...

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Autores principales:	A. Marieke Oudelaar, Caroline L. Harrold, Lars L. P. Hanssen, Jelena M. Telenius, Douglas R. Higgs, Jim R. Hughes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8c56dab7a74b4c60ab85d1cab13fd72b
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spelling	oai:doaj.org-article:8c56dab7a74b4c60ab85d1cab13fd72b2021-12-02T16:58:29ZA revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus10.1038/s41467-019-13404-x2041-1723https://doaj.org/article/8c56dab7a74b4c60ab85d1cab13fd72b2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13404-xhttps://doaj.org/toc/2041-1723The coordination of interactions between multiple regulatory elements and genes within a chromatin domain remains poorly understood. Here, the authors use a method to detect multi-way chromatin interactions in a mouse model in which the α-globin domain is extended to include several additional genes, finding that the promoters do not form mutually exclusive interactions with the enhancers, but all interact simultaneously in a single complex.A. Marieke OudelaarCaroline L. HarroldLars L. P. HanssenJelena M. TeleniusDouglas R. HiggsJim R. HughesNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q A. Marieke Oudelaar Caroline L. Harrold Lars L. P. Hanssen Jelena M. Telenius Douglas R. Higgs Jim R. Hughes A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus
description	The coordination of interactions between multiple regulatory elements and genes within a chromatin domain remains poorly understood. Here, the authors use a method to detect multi-way chromatin interactions in a mouse model in which the α-globin domain is extended to include several additional genes, finding that the promoters do not form mutually exclusive interactions with the enhancers, but all interact simultaneously in a single complex.
format	article
author	A. Marieke Oudelaar Caroline L. Harrold Lars L. P. Hanssen Jelena M. Telenius Douglas R. Higgs Jim R. Hughes
author_facet	A. Marieke Oudelaar Caroline L. Harrold Lars L. P. Hanssen Jelena M. Telenius Douglas R. Higgs Jim R. Hughes
author_sort	A. Marieke Oudelaar
title	A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus
title_short	A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus
title_full	A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus
title_fullStr	A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus
title_full_unstemmed	A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus
title_sort	revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8c56dab7a74b4c60ab85d1cab13fd72b
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A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus

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