Non-CG methylation and multiple histone profiles associate child abuse with immune and small GTPase dysregulation

Non-CG methylation and multiple histone profiles associate child abuse with immune and small GTPase dysregulation

Early-life adversity is thought to increase the risk of psychopathology through epigenetic mechanisms. Here, the authors profile 6 histone marks, chromatin states and DNA methylation in the lateral amygdala in subjects with a history of early-life adversity.

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Autores principales: Pierre-Eric Lutz, Marc-Aurèle Chay, Alain Pacis, Gary G. Chen, Zahia Aouabed, Elisabetta Maffioletti, Jean-François Théroux, Jean-Christophe Grenier, Jennie Yang, Maria Aguirre, Carl Ernst, Adriana Redensek, Léon C. van Kempen, Ipek Yalcin, Tony Kwan, Naguib Mechawar, Tomi Pastinen, Gustavo Turecki
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/8c5757658d8b418787c5d3069801d997
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https://doaj.org/article/8c5757658d8b418787c5d3069801d997

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