SFPQ rescues F508del-CFTR expression and function in cystic fibrosis bronchial epithelial cells

SFPQ rescues F508del-CFTR expression and function in cystic fibrosis bronchial epithelial cells

Abstract Cystic fibrosis (CF) occurs as a result of mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which lead to misfolding, trafficking defects, and impaired function of the CFTR protein. Splicing factor proline/glutamine-rich (SFPQ) is a multifunctional nuclear R...

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Main Authors: Parameet Kumar, Dharmendra Kumar Soni, Chaitali Sen, Mads B. Larsen, Krystyna Mazan-Mamczarz, Yulan Piao, Supriyo De, Myriam Gorospe, Raymond A. Frizzell, Roopa Biswas
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/8c85c837ff6341c9a9a4cf53d4a47860
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https://doaj.org/article/8c85c837ff6341c9a9a4cf53d4a47860

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