The CRISPR Spacer Space Is Dominated by Sequences from Species-Specific Mobilomes

ABSTRACT Clustered regularly interspaced short palindromic repeats and CRISPR-associated protein (CRISPR-Cas) systems store the memory of past encounters with foreign DNA in unique spacers that are inserted between direct repeats in CRISPR arrays. For only a small fraction of the spacers, homologous...

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Autores principales: Sergey A. Shmakov, Vassilii Sitnik, Kira S. Makarova, Yuri I. Wolf, Konstantin V. Severinov, Eugene V. Koonin
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2017
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Acceso en línea:https://doaj.org/article/8c876cbf1aa040bc86fed2699abe75c8
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