Synthesis, Characterization, Antioxidant Activity, and Toxicity Properties of Tripolyphosphate Crosslinked Chitosan

Chitosan is biopolymer obtained from chitin deacetylation reaction. Chitin is a constituent of shrimps’ outer shell. Chitosan modification using crosslinker agent could increase the active groups and stabilize the physical character. One of non-toxic crosslink agents was tripolyphosphate. This study...

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Autores principales:	Tien Setyaningtyas, Kapti riyani, Mardiyah Kurniasih, Purwati Purwati, Siti Masruroh
Formato:	article
Lenguaje:	EN ID
Publicado:	Jenderal Soedirman University 2021
Materias:	Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/8c8abad5619740a3bbb6c332ba366eb4
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spelling	oai:doaj.org-article:8c8abad5619740a3bbb6c332ba366eb42021-11-22T01:13:55ZSynthesis, Characterization, Antioxidant Activity, and Toxicity Properties of Tripolyphosphate Crosslinked Chitosan1907-97612503-031010.20884/1.jm.2021.16.3.815https://doaj.org/article/8c8abad5619740a3bbb6c332ba366eb42021-11-01T00:00:00Zhttps://ojs.jmolekul.com/ojs/index.php/jm/article/view/815https://doaj.org/toc/1907-9761https://doaj.org/toc/2503-0310Chitosan is biopolymer obtained from chitin deacetylation reaction. Chitin is a constituent of shrimps’ outer shell. Chitosan modification using crosslinker agent could increase the active groups and stabilize the physical character. One of non-toxic crosslink agents was tripolyphosphate. This study aimed at synthesizing tripolyphosphate crosslinked chitosan (TPP-Cs) to test the antioxidant and toxicity. Synthesizing tripolyphosphate chitosan was conducted using ionic gelation method. The antioxidant activity test was studied from DPPH radicals scavenging and the ability to inhibit linoleic acid oxidation. The toxicity test was using BSLT (Brine Shrimp Lethality Test) method and Artemia salina leach nauplii. The study showed that TPP-Cs could be synthesized from pink shrimp and showed antioxidant activity. The activity was due to amino and hydroxyl groups. The BSLT method showed that TPP-Cs had the potential to be applied for antibacterial, antivirus, or anticancer products.Tien SetyaningtyasKapti riyaniMardiyah KurniasihPurwati PurwatiSiti MasrurohJenderal Soedirman UniversityarticleChemistryQD1-999ENIDMolekul, Vol 16, Iss 3, Pp 251-259 (2021)
institution	DOAJ
collection	DOAJ
language	EN ID
topic	Chemistry QD1-999
spellingShingle	Chemistry QD1-999 Tien Setyaningtyas Kapti riyani Mardiyah Kurniasih Purwati Purwati Siti Masruroh Synthesis, Characterization, Antioxidant Activity, and Toxicity Properties of Tripolyphosphate Crosslinked Chitosan
description	Chitosan is biopolymer obtained from chitin deacetylation reaction. Chitin is a constituent of shrimps’ outer shell. Chitosan modification using crosslinker agent could increase the active groups and stabilize the physical character. One of non-toxic crosslink agents was tripolyphosphate. This study aimed at synthesizing tripolyphosphate crosslinked chitosan (TPP-Cs) to test the antioxidant and toxicity. Synthesizing tripolyphosphate chitosan was conducted using ionic gelation method. The antioxidant activity test was studied from DPPH radicals scavenging and the ability to inhibit linoleic acid oxidation. The toxicity test was using BSLT (Brine Shrimp Lethality Test) method and Artemia salina leach nauplii. The study showed that TPP-Cs could be synthesized from pink shrimp and showed antioxidant activity. The activity was due to amino and hydroxyl groups. The BSLT method showed that TPP-Cs had the potential to be applied for antibacterial, antivirus, or anticancer products.
format	article
author	Tien Setyaningtyas Kapti riyani Mardiyah Kurniasih Purwati Purwati Siti Masruroh
author_facet	Tien Setyaningtyas Kapti riyani Mardiyah Kurniasih Purwati Purwati Siti Masruroh
author_sort	Tien Setyaningtyas
title	Synthesis, Characterization, Antioxidant Activity, and Toxicity Properties of Tripolyphosphate Crosslinked Chitosan
title_short	Synthesis, Characterization, Antioxidant Activity, and Toxicity Properties of Tripolyphosphate Crosslinked Chitosan
title_full	Synthesis, Characterization, Antioxidant Activity, and Toxicity Properties of Tripolyphosphate Crosslinked Chitosan
title_fullStr	Synthesis, Characterization, Antioxidant Activity, and Toxicity Properties of Tripolyphosphate Crosslinked Chitosan
title_full_unstemmed	Synthesis, Characterization, Antioxidant Activity, and Toxicity Properties of Tripolyphosphate Crosslinked Chitosan
title_sort	synthesis, characterization, antioxidant activity, and toxicity properties of tripolyphosphate crosslinked chitosan
publisher	Jenderal Soedirman University
publishDate	2021
url	https://doaj.org/article/8c8abad5619740a3bbb6c332ba366eb4
work_keys_str_mv	AT tiensetyaningtyas synthesischaracterizationantioxidantactivityandtoxicitypropertiesoftripolyphosphatecrosslinkedchitosan AT kaptiriyani synthesischaracterizationantioxidantactivityandtoxicitypropertiesoftripolyphosphatecrosslinkedchitosan AT mardiyahkurniasih synthesischaracterizationantioxidantactivityandtoxicitypropertiesoftripolyphosphatecrosslinkedchitosan AT purwatipurwati synthesischaracterizationantioxidantactivityandtoxicitypropertiesoftripolyphosphatecrosslinkedchitosan AT sitimasruroh synthesischaracterizationantioxidantactivityandtoxicitypropertiesoftripolyphosphatecrosslinkedchitosan
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Synthesis, Characterization, Antioxidant Activity, and Toxicity Properties of Tripolyphosphate Crosslinked Chitosan

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