Glucocorticoid resistance conferring mutation in the C-terminus of GR alters the receptor conformational dynamics

Abstract The glucocorticoid receptor is a key regulator of essential physiological processes, which under the control of the Hsp90 chaperone machinery, binds to steroid hormones and steroid-like molecules and in a rather complicated and elusive response, regulates a set of glucocorticoid responsive...

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Autores principales: Anna Kaziales, Florian Rührnößl, Klaus Richter
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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R
Q
Acceso en línea:https://doaj.org/article/8c9e6a950a04427ab5b02f857827df8d
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