Expedient syntheses of N-heterocycles via intermolecular amphoteric diamination of allenes

Saturated N-heterocycle rings are common structural motifs of many FDA-approved drugs. Here, the authors show that a metal-free amphoteric diamination of allenes produces valuable six-, seven- and eight-membered N-heterocycles with high diversity and tolerance of functional groups on the ring.

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Autores principales:	Zhishi Ye, Sarju Adhikari, Yu Xia, Mingji Dai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8caaea6b48b349a2bd81dbba2adf1081
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spelling	oai:doaj.org-article:8caaea6b48b349a2bd81dbba2adf10812021-12-02T16:50:07ZExpedient syntheses of N-heterocycles via intermolecular amphoteric diamination of allenes10.1038/s41467-018-03085-32041-1723https://doaj.org/article/8caaea6b48b349a2bd81dbba2adf10812018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03085-3https://doaj.org/toc/2041-1723Saturated N-heterocycle rings are common structural motifs of many FDA-approved drugs. Here, the authors show that a metal-free amphoteric diamination of allenes produces valuable six-, seven- and eight-membered N-heterocycles with high diversity and tolerance of functional groups on the ring.Zhishi YeSarju AdhikariYu XiaMingji DaiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhishi Ye Sarju Adhikari Yu Xia Mingji Dai Expedient syntheses of N-heterocycles via intermolecular amphoteric diamination of allenes
description	Saturated N-heterocycle rings are common structural motifs of many FDA-approved drugs. Here, the authors show that a metal-free amphoteric diamination of allenes produces valuable six-, seven- and eight-membered N-heterocycles with high diversity and tolerance of functional groups on the ring.
format	article
author	Zhishi Ye Sarju Adhikari Yu Xia Mingji Dai
author_facet	Zhishi Ye Sarju Adhikari Yu Xia Mingji Dai
author_sort	Zhishi Ye
title	Expedient syntheses of N-heterocycles via intermolecular amphoteric diamination of allenes
title_short	Expedient syntheses of N-heterocycles via intermolecular amphoteric diamination of allenes
title_full	Expedient syntheses of N-heterocycles via intermolecular amphoteric diamination of allenes
title_fullStr	Expedient syntheses of N-heterocycles via intermolecular amphoteric diamination of allenes
title_full_unstemmed	Expedient syntheses of N-heterocycles via intermolecular amphoteric diamination of allenes
title_sort	expedient syntheses of n-heterocycles via intermolecular amphoteric diamination of allenes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8caaea6b48b349a2bd81dbba2adf1081
work_keys_str_mv	AT zhishiye expedientsynthesesofnheterocyclesviaintermolecularamphotericdiaminationofallenes AT sarjuadhikari expedientsynthesesofnheterocyclesviaintermolecularamphotericdiaminationofallenes AT yuxia expedientsynthesesofnheterocyclesviaintermolecularamphotericdiaminationofallenes AT mingjidai expedientsynthesesofnheterocyclesviaintermolecularamphotericdiaminationofallenes
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Expedient syntheses of N-heterocycles via intermolecular amphoteric diamination of allenes

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