Inhibition of MRN activity by a telomere protein motif
Telomeres suppress the DNA damage response at chromosome ends. Here the authors show that in budding yeast the activity of the MRX complex in DNA repair and DNA damage signaling is inhibited by telomeric protein Rif2 via a short motif at the N-terminus.
Guardado en:
| Autores principales: | , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/8cecf44805f740329669d3853d59d8f7 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:8cecf44805f740329669d3853d59d8f7 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:8cecf44805f740329669d3853d59d8f72021-12-02T17:14:22ZInhibition of MRN activity by a telomere protein motif10.1038/s41467-021-24047-22041-1723https://doaj.org/article/8cecf44805f740329669d3853d59d8f72021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24047-2https://doaj.org/toc/2041-1723Telomeres suppress the DNA damage response at chromosome ends. Here the authors show that in budding yeast the activity of the MRX complex in DNA repair and DNA damage signaling is inhibited by telomeric protein Rif2 via a short motif at the N-terminus.Freddy KhayatElda CannavoMajedh AlshmeryWilliam R. FosterCharly ChahwanMartino MaddalenaChristopher SmithAntony W. OliverAdam T. WatsonAntony M. CarrPetr CejkaAlessandro BianchiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Freddy Khayat Elda Cannavo Majedh Alshmery William R. Foster Charly Chahwan Martino Maddalena Christopher Smith Antony W. Oliver Adam T. Watson Antony M. Carr Petr Cejka Alessandro Bianchi Inhibition of MRN activity by a telomere protein motif |
| description |
Telomeres suppress the DNA damage response at chromosome ends. Here the authors show that in budding yeast the activity of the MRX complex in DNA repair and DNA damage signaling is inhibited by telomeric protein Rif2 via a short motif at the N-terminus. |
| format |
article |
| author |
Freddy Khayat Elda Cannavo Majedh Alshmery William R. Foster Charly Chahwan Martino Maddalena Christopher Smith Antony W. Oliver Adam T. Watson Antony M. Carr Petr Cejka Alessandro Bianchi |
| author_facet |
Freddy Khayat Elda Cannavo Majedh Alshmery William R. Foster Charly Chahwan Martino Maddalena Christopher Smith Antony W. Oliver Adam T. Watson Antony M. Carr Petr Cejka Alessandro Bianchi |
| author_sort |
Freddy Khayat |
| title |
Inhibition of MRN activity by a telomere protein motif |
| title_short |
Inhibition of MRN activity by a telomere protein motif |
| title_full |
Inhibition of MRN activity by a telomere protein motif |
| title_fullStr |
Inhibition of MRN activity by a telomere protein motif |
| title_full_unstemmed |
Inhibition of MRN activity by a telomere protein motif |
| title_sort |
inhibition of mrn activity by a telomere protein motif |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/8cecf44805f740329669d3853d59d8f7 |
| work_keys_str_mv |
AT freddykhayat inhibitionofmrnactivitybyatelomereproteinmotif AT eldacannavo inhibitionofmrnactivitybyatelomereproteinmotif AT majedhalshmery inhibitionofmrnactivitybyatelomereproteinmotif AT williamrfoster inhibitionofmrnactivitybyatelomereproteinmotif AT charlychahwan inhibitionofmrnactivitybyatelomereproteinmotif AT martinomaddalena inhibitionofmrnactivitybyatelomereproteinmotif AT christophersmith inhibitionofmrnactivitybyatelomereproteinmotif AT antonywoliver inhibitionofmrnactivitybyatelomereproteinmotif AT adamtwatson inhibitionofmrnactivitybyatelomereproteinmotif AT antonymcarr inhibitionofmrnactivitybyatelomereproteinmotif AT petrcejka inhibitionofmrnactivitybyatelomereproteinmotif AT alessandrobianchi inhibitionofmrnactivitybyatelomereproteinmotif |
| _version_ |
1718381330775932928 |