ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma

Spiradenoma and cylindroma are skin adnexal tumors that can behave aggressively and undergo malignant transformation. Here, the authors genetically assess a cohort of these adnexal tumours, highlighting recurrent ALPK1 mutations and revealing the genomic landscape of these rare tumours.

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Autores principales:	Mamunur Rashid, Michiel van der Horst, Thomas Mentzel, Francesca Butera, Ingrid Ferreira, Alena Pance, Arno Rütten, Bostjan Luzar, Zlatko Marusic, Nicolas de Saint Aubain, Jennifer S. Ko, Steven D. Billings, Sofia Chen, Marie Abi Daoud, James Hewinson, Sandra Louzada, Paul W. Harms, Guia Cerretelli, Carla Daniela Robles-Espinoza, Rajiv M. Patel, Louise van der Weyden, Chris Bakal, Jason L. Hornick, Mark J. Arends, Thomas Brenn, David J. Adams
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8cf5f1bae6714e01b43eb450dac4bb01
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spelling	oai:doaj.org-article:8cf5f1bae6714e01b43eb450dac4bb012021-12-02T16:58:27ZALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma10.1038/s41467-019-09979-02041-1723https://doaj.org/article/8cf5f1bae6714e01b43eb450dac4bb012019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09979-0https://doaj.org/toc/2041-1723Spiradenoma and cylindroma are skin adnexal tumors that can behave aggressively and undergo malignant transformation. Here, the authors genetically assess a cohort of these adnexal tumours, highlighting recurrent ALPK1 mutations and revealing the genomic landscape of these rare tumours.Mamunur RashidMichiel van der HorstThomas MentzelFrancesca ButeraIngrid FerreiraAlena PanceArno RüttenBostjan LuzarZlatko MarusicNicolas de Saint AubainJennifer S. KoSteven D. BillingsSofia ChenMarie Abi DaoudJames HewinsonSandra LouzadaPaul W. HarmsGuia CerretelliCarla Daniela Robles-EspinozaRajiv M. PatelLouise van der WeydenChris BakalJason L. HornickMark J. ArendsThomas BrennDavid J. AdamsNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mamunur Rashid Michiel van der Horst Thomas Mentzel Francesca Butera Ingrid Ferreira Alena Pance Arno Rütten Bostjan Luzar Zlatko Marusic Nicolas de Saint Aubain Jennifer S. Ko Steven D. Billings Sofia Chen Marie Abi Daoud James Hewinson Sandra Louzada Paul W. Harms Guia Cerretelli Carla Daniela Robles-Espinoza Rajiv M. Patel Louise van der Weyden Chris Bakal Jason L. Hornick Mark J. Arends Thomas Brenn David J. Adams ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma
description	Spiradenoma and cylindroma are skin adnexal tumors that can behave aggressively and undergo malignant transformation. Here, the authors genetically assess a cohort of these adnexal tumours, highlighting recurrent ALPK1 mutations and revealing the genomic landscape of these rare tumours.
format	article
author	Mamunur Rashid Michiel van der Horst Thomas Mentzel Francesca Butera Ingrid Ferreira Alena Pance Arno Rütten Bostjan Luzar Zlatko Marusic Nicolas de Saint Aubain Jennifer S. Ko Steven D. Billings Sofia Chen Marie Abi Daoud James Hewinson Sandra Louzada Paul W. Harms Guia Cerretelli Carla Daniela Robles-Espinoza Rajiv M. Patel Louise van der Weyden Chris Bakal Jason L. Hornick Mark J. Arends Thomas Brenn David J. Adams
author_facet	Mamunur Rashid Michiel van der Horst Thomas Mentzel Francesca Butera Ingrid Ferreira Alena Pance Arno Rütten Bostjan Luzar Zlatko Marusic Nicolas de Saint Aubain Jennifer S. Ko Steven D. Billings Sofia Chen Marie Abi Daoud James Hewinson Sandra Louzada Paul W. Harms Guia Cerretelli Carla Daniela Robles-Espinoza Rajiv M. Patel Louise van der Weyden Chris Bakal Jason L. Hornick Mark J. Arends Thomas Brenn David J. Adams
author_sort	Mamunur Rashid
title	ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma
title_short	ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma
title_full	ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma
title_fullStr	ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma
title_full_unstemmed	ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma
title_sort	alpk1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8cf5f1bae6714e01b43eb450dac4bb01
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ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma

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