Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives
Ebselen is an organoselenium drug that inhibits the SARS-CoV-2 main protease (Mpro). Here, the authors co-crystallised Mpro with ebselen and an ebselen derivative and observed an enzyme bound organoselenium covalent adduct in the crystal structures, which was also confirmed by mass spectrometry anal...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2021
|
| Subjects: | |
| Online Access: | https://doaj.org/article/8cf917f0f0d94c58998c45d6d9518f5b |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|