Influenza virus neuraminidase regulates host CD8+ T-cell response in mice
Chung-Yi Wu et al. demonstrate a role of neuraminidase (NA) for Influenza A viruse (IAV)-specific CD8+ T-cell response and virion assembly. When mice are vaccinated with the live attenuated NA-defective IAV, they are protected from the upcoming IAV infection. This study provides insights into the de...
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| Autores principales: | , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2020
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/8d119900ef2c4a00b2a69ffd6a6d5bb5 |
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| Sumario: | Chung-Yi Wu et al. demonstrate a role of neuraminidase (NA) for Influenza A viruse (IAV)-specific CD8+ T-cell response and virion assembly. When mice are vaccinated with the live attenuated NA-defective IAV, they are protected from the upcoming IAV infection. This study provides insights into the development strategies of universal influenza vaccines. |
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