Influenza virus neuraminidase regulates host CD8+ T-cell response in mice

Chung-Yi Wu et al. demonstrate a role of neuraminidase (NA) for Influenza A viruse (IAV)-specific CD8+ T-cell response and virion assembly. When mice are vaccinated with the live attenuated NA-defective IAV, they are protected from the upcoming IAV infection. This study provides insights into the de...

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Autores principales:	Chung-Yi Wu, Hong-Yang Chuang, Chi-Huey Wong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8d119900ef2c4a00b2a69ffd6a6d5bb5
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spelling	oai:doaj.org-article:8d119900ef2c4a00b2a69ffd6a6d5bb52021-12-02T12:33:13ZInfluenza virus neuraminidase regulates host CD8+ T-cell response in mice10.1038/s42003-020-01486-z2399-3642https://doaj.org/article/8d119900ef2c4a00b2a69ffd6a6d5bb52020-12-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01486-zhttps://doaj.org/toc/2399-3642Chung-Yi Wu et al. demonstrate a role of neuraminidase (NA) for Influenza A viruse (IAV)-specific CD8+ T-cell response and virion assembly. When mice are vaccinated with the live attenuated NA-defective IAV, they are protected from the upcoming IAV infection. This study provides insights into the development strategies of universal influenza vaccines.Chung-Yi WuHong-Yang ChuangChi-Huey WongNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 3, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Chung-Yi Wu Hong-Yang Chuang Chi-Huey Wong Influenza virus neuraminidase regulates host CD8+ T-cell response in mice
description	Chung-Yi Wu et al. demonstrate a role of neuraminidase (NA) for Influenza A viruse (IAV)-specific CD8+ T-cell response and virion assembly. When mice are vaccinated with the live attenuated NA-defective IAV, they are protected from the upcoming IAV infection. This study provides insights into the development strategies of universal influenza vaccines.
format	article
author	Chung-Yi Wu Hong-Yang Chuang Chi-Huey Wong
author_facet	Chung-Yi Wu Hong-Yang Chuang Chi-Huey Wong
author_sort	Chung-Yi Wu
title	Influenza virus neuraminidase regulates host CD8+ T-cell response in mice
title_short	Influenza virus neuraminidase regulates host CD8+ T-cell response in mice
title_full	Influenza virus neuraminidase regulates host CD8+ T-cell response in mice
title_fullStr	Influenza virus neuraminidase regulates host CD8+ T-cell response in mice
title_full_unstemmed	Influenza virus neuraminidase regulates host CD8+ T-cell response in mice
title_sort	influenza virus neuraminidase regulates host cd8+ t-cell response in mice
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8d119900ef2c4a00b2a69ffd6a6d5bb5
work_keys_str_mv	AT chungyiwu influenzavirusneuraminidaseregulateshostcd8tcellresponseinmice AT hongyangchuang influenzavirusneuraminidaseregulateshostcd8tcellresponseinmice AT chihueywong influenzavirusneuraminidaseregulateshostcd8tcellresponseinmice
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Influenza virus neuraminidase regulates host CD8+ T-cell response in mice

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