Chromatin loops as allosteric modulators of enhancer-promoter interactions.

The classic model of eukaryotic gene expression requires direct spatial contact between a distal enhancer and a proximal promoter. Recent Chromosome Conformation Capture (3C) studies show that enhancers and promoters are embedded in a complex network of looping interactions. Here we use a polymer mo...

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Autores principales: Boryana Doyle, Geoffrey Fudenberg, Maxim Imakaev, Leonid A Mirny
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/8d1427eb59f74f52ac8f9ea6a2aaf2a3
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