Metal ions and sugar puckering balance single-molecule kinetic heterogeneity in RNA and DNA tertiary contacts

Mobile group II introns function as ribozymes to splice and reinsert themselves into DNA, thereby colonizing new genomic regions. Here the authors use single-molecule FRET and molecular dynamics simulations to reveal a structural link between metal ion induced kinetic heterogeneity and the sugar puc...

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Autores principales: Fabio D. Steffen, Mokrane Khier, Danny Kowerko, Richard A. Cunha, Richard Börner, Roland K. O. Sigel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/8d43dc002f1d4cfa8c1f9fe4d715405c
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