Metal ions and sugar puckering balance single-molecule kinetic heterogeneity in RNA and DNA tertiary contacts

Mobile group II introns function as ribozymes to splice and reinsert themselves into DNA, thereby colonizing new genomic regions. Here the authors use single-molecule FRET and molecular dynamics simulations to reveal a structural link between metal ion induced kinetic heterogeneity and the sugar puc...

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Autores principales:	Fabio D. Steffen, Mokrane Khier, Danny Kowerko, Richard A. Cunha, Richard Börner, Roland K. O. Sigel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8d43dc002f1d4cfa8c1f9fe4d715405c
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spelling	oai:doaj.org-article:8d43dc002f1d4cfa8c1f9fe4d715405c2021-12-02T15:39:27ZMetal ions and sugar puckering balance single-molecule kinetic heterogeneity in RNA and DNA tertiary contacts10.1038/s41467-019-13683-42041-1723https://doaj.org/article/8d43dc002f1d4cfa8c1f9fe4d715405c2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13683-4https://doaj.org/toc/2041-1723Mobile group II introns function as ribozymes to splice and reinsert themselves into DNA, thereby colonizing new genomic regions. Here the authors use single-molecule FRET and molecular dynamics simulations to reveal a structural link between metal ion induced kinetic heterogeneity and the sugar puckers at the exon-intron binding interface.Fabio D. SteffenMokrane KhierDanny KowerkoRichard A. CunhaRichard BörnerRoland K. O. SigelNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fabio D. Steffen Mokrane Khier Danny Kowerko Richard A. Cunha Richard Börner Roland K. O. Sigel Metal ions and sugar puckering balance single-molecule kinetic heterogeneity in RNA and DNA tertiary contacts
description	Mobile group II introns function as ribozymes to splice and reinsert themselves into DNA, thereby colonizing new genomic regions. Here the authors use single-molecule FRET and molecular dynamics simulations to reveal a structural link between metal ion induced kinetic heterogeneity and the sugar puckers at the exon-intron binding interface.
format	article
author	Fabio D. Steffen Mokrane Khier Danny Kowerko Richard A. Cunha Richard Börner Roland K. O. Sigel
author_facet	Fabio D. Steffen Mokrane Khier Danny Kowerko Richard A. Cunha Richard Börner Roland K. O. Sigel
author_sort	Fabio D. Steffen
title	Metal ions and sugar puckering balance single-molecule kinetic heterogeneity in RNA and DNA tertiary contacts
title_short	Metal ions and sugar puckering balance single-molecule kinetic heterogeneity in RNA and DNA tertiary contacts
title_full	Metal ions and sugar puckering balance single-molecule kinetic heterogeneity in RNA and DNA tertiary contacts
title_fullStr	Metal ions and sugar puckering balance single-molecule kinetic heterogeneity in RNA and DNA tertiary contacts
title_full_unstemmed	Metal ions and sugar puckering balance single-molecule kinetic heterogeneity in RNA and DNA tertiary contacts
title_sort	metal ions and sugar puckering balance single-molecule kinetic heterogeneity in rna and dna tertiary contacts
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8d43dc002f1d4cfa8c1f9fe4d715405c
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Metal ions and sugar puckering balance single-molecule kinetic heterogeneity in RNA and DNA tertiary contacts

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