Tumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma

Tumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma

The Sonic Hedgehog subgroup of medulloblastoma are characterised by the high infiltration of tumour-associated macrophages (TAMs). Here, the authors show that TAM numbers in patients are associated with better prognosis and that, consistently, in a murine model of medulloblastoma, these TAMs have an...

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Main Authors: Victor Maximov, Zhihong Chen, Yun Wei, M. Hope Robinson, Cameron J. Herting, Nithya S. Shanmugam, Vasilisa A. Rudneva, Kelly C. Goldsmith, Tobey J. MacDonald, Paul A. Northcott, Dolores Hambardzumyan, Anna M. Kenney
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
Q
Online Access:https://doaj.org/article/8d9bcf366d79419c9f9e965c3c18cd6f
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Summary:The Sonic Hedgehog subgroup of medulloblastoma are characterised by the high infiltration of tumour-associated macrophages (TAMs). Here, the authors show that TAM numbers in patients are associated with better prognosis and that, consistently, in a murine model of medulloblastoma, these TAMs have anti-tumoural properties.

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