Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations

Polygenic scores (PGS) are often based on GWAS data from individuals of European ancestry, thus limiting their use in populations of non-European ancestry. Here, the authors predict the relative accuracy of PGS across ancestries and suggest that causal variants are mostly shared across continents.

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Auteurs principaux: Ying Wang, Jing Guo, Guiyan Ni, Jian Yang, Peter M. Visscher, Loic Yengo
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/8dac5eebf7ee40489c3b6857629f64e9
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