Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations
Polygenic scores (PGS) are often based on GWAS data from individuals of European ancestry, thus limiting their use in populations of non-European ancestry. Here, the authors predict the relative accuracy of PGS across ancestries and suggest that causal variants are mostly shared across continents.
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| Autores principales: | , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2020
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/8dac5eebf7ee40489c3b6857629f64e9 |
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| Sumario: | Polygenic scores (PGS) are often based on GWAS data from individuals of European ancestry, thus limiting their use in populations of non-European ancestry. Here, the authors predict the relative accuracy of PGS across ancestries and suggest that causal variants are mostly shared across continents. |
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