Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations

Polygenic scores (PGS) are often based on GWAS data from individuals of European ancestry, thus limiting their use in populations of non-European ancestry. Here, the authors predict the relative accuracy of PGS across ancestries and suggest that causal variants are mostly shared across continents.

Guardado en:

Detalles Bibliográficos
Autores principales:	Ying Wang, Jing Guo, Guiyan Ni, Jian Yang, Peter M. Visscher, Loic Yengo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8dac5eebf7ee40489c3b6857629f64e9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8dac5eebf7ee40489c3b6857629f64e9
record_format	dspace
spelling	oai:doaj.org-article:8dac5eebf7ee40489c3b6857629f64e92021-12-02T16:24:57ZTheoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations10.1038/s41467-020-17719-y2041-1723https://doaj.org/article/8dac5eebf7ee40489c3b6857629f64e92020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17719-yhttps://doaj.org/toc/2041-1723Polygenic scores (PGS) are often based on GWAS data from individuals of European ancestry, thus limiting their use in populations of non-European ancestry. Here, the authors predict the relative accuracy of PGS across ancestries and suggest that causal variants are mostly shared across continents.Ying WangJing GuoGuiyan NiJian YangPeter M. VisscherLoic YengoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ying Wang Jing Guo Guiyan Ni Jian Yang Peter M. Visscher Loic Yengo Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations
description	Polygenic scores (PGS) are often based on GWAS data from individuals of European ancestry, thus limiting their use in populations of non-European ancestry. Here, the authors predict the relative accuracy of PGS across ancestries and suggest that causal variants are mostly shared across continents.
format	article
author	Ying Wang Jing Guo Guiyan Ni Jian Yang Peter M. Visscher Loic Yengo
author_facet	Ying Wang Jing Guo Guiyan Ni Jian Yang Peter M. Visscher Loic Yengo
author_sort	Ying Wang
title	Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations
title_short	Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations
title_full	Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations
title_fullStr	Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations
title_full_unstemmed	Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations
title_sort	theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8dac5eebf7ee40489c3b6857629f64e9
work_keys_str_mv	AT yingwang theoreticalandempiricalquantificationoftheaccuracyofpolygenicscoresinancestrydivergentpopulations AT jingguo theoreticalandempiricalquantificationoftheaccuracyofpolygenicscoresinancestrydivergentpopulations AT guiyanni theoreticalandempiricalquantificationoftheaccuracyofpolygenicscoresinancestrydivergentpopulations AT jianyang theoreticalandempiricalquantificationoftheaccuracyofpolygenicscoresinancestrydivergentpopulations AT petermvisscher theoreticalandempiricalquantificationoftheaccuracyofpolygenicscoresinancestrydivergentpopulations AT loicyengo theoreticalandempiricalquantificationoftheaccuracyofpolygenicscoresinancestrydivergentpopulations
_version_	1718384066805366784

Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations

Ejemplares similares