Obesity-associated NLRC4 inflammasome activation drives breast cancer progression

Obesity is associated with higher breast cancer risk and poor prognosis. Here, the authors show that obesity promotes breast cancer through the recruitment of macrophages with activated NLRC4 inflammasome, which activate IL-1β production, resulting in VEGFA expression in adipocytes and angiogenesis....

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Autores principales:	Ryan Kolb, Liem Phan, Nicholas Borcherding, Yinghong Liu, Fang Yuan, Ann M. Janowski, Qing Xie, Kathleen R. Markan, Wei Li, Matthew J. Potthoff, Enrique Fuentes-Mattei, Lesley G. Ellies, C. Michael Knudson, Mong-Hong Lee, Sai-Ching J. Yeung, Suzanne L. Cassel, Fayyaz S. Sutterwala, Weizhou Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8dc39d9da6c541818c16001eb4cc7191
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spelling	oai:doaj.org-article:8dc39d9da6c541818c16001eb4cc71912021-12-02T16:49:56ZObesity-associated NLRC4 inflammasome activation drives breast cancer progression10.1038/ncomms130072041-1723https://doaj.org/article/8dc39d9da6c541818c16001eb4cc71912016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13007https://doaj.org/toc/2041-1723Obesity is associated with higher breast cancer risk and poor prognosis. Here, the authors show that obesity promotes breast cancer through the recruitment of macrophages with activated NLRC4 inflammasome, which activate IL-1β production, resulting in VEGFA expression in adipocytes and angiogenesis.Ryan KolbLiem PhanNicholas BorcherdingYinghong LiuFang YuanAnn M. JanowskiQing XieKathleen R. MarkanWei LiMatthew J. PotthoffEnrique Fuentes-MatteiLesley G. ElliesC. Michael KnudsonMong-Hong LeeSai-Ching J. YeungSuzanne L. CasselFayyaz S. SutterwalaWeizhou ZhangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ryan Kolb Liem Phan Nicholas Borcherding Yinghong Liu Fang Yuan Ann M. Janowski Qing Xie Kathleen R. Markan Wei Li Matthew J. Potthoff Enrique Fuentes-Mattei Lesley G. Ellies C. Michael Knudson Mong-Hong Lee Sai-Ching J. Yeung Suzanne L. Cassel Fayyaz S. Sutterwala Weizhou Zhang Obesity-associated NLRC4 inflammasome activation drives breast cancer progression
description	Obesity is associated with higher breast cancer risk and poor prognosis. Here, the authors show that obesity promotes breast cancer through the recruitment of macrophages with activated NLRC4 inflammasome, which activate IL-1β production, resulting in VEGFA expression in adipocytes and angiogenesis.
format	article
author	Ryan Kolb Liem Phan Nicholas Borcherding Yinghong Liu Fang Yuan Ann M. Janowski Qing Xie Kathleen R. Markan Wei Li Matthew J. Potthoff Enrique Fuentes-Mattei Lesley G. Ellies C. Michael Knudson Mong-Hong Lee Sai-Ching J. Yeung Suzanne L. Cassel Fayyaz S. Sutterwala Weizhou Zhang
author_facet	Ryan Kolb Liem Phan Nicholas Borcherding Yinghong Liu Fang Yuan Ann M. Janowski Qing Xie Kathleen R. Markan Wei Li Matthew J. Potthoff Enrique Fuentes-Mattei Lesley G. Ellies C. Michael Knudson Mong-Hong Lee Sai-Ching J. Yeung Suzanne L. Cassel Fayyaz S. Sutterwala Weizhou Zhang
author_sort	Ryan Kolb
title	Obesity-associated NLRC4 inflammasome activation drives breast cancer progression
title_short	Obesity-associated NLRC4 inflammasome activation drives breast cancer progression
title_full	Obesity-associated NLRC4 inflammasome activation drives breast cancer progression
title_fullStr	Obesity-associated NLRC4 inflammasome activation drives breast cancer progression
title_full_unstemmed	Obesity-associated NLRC4 inflammasome activation drives breast cancer progression
title_sort	obesity-associated nlrc4 inflammasome activation drives breast cancer progression
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/8dc39d9da6c541818c16001eb4cc7191
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Obesity-associated NLRC4 inflammasome activation drives breast cancer progression

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