Cinnamophilin overcomes cancer multi-drug resistance via allosterically modulating human P-glycoprotein on both drug binding sites and ATPase binding sites

Cinnamophilin overcomes cancer multi-drug resistance via allosterically modulating human P-glycoprotein on both drug binding sites and ATPase binding sites

Cancer multi-drug resistance (MDR) caused by P-glycoprotein (P-gp) efflux is a critical unresolved clinical concern. The present study analyzed the effect of cinnamophilin on P-gp inhibition and MDR reversion. The effect of cinnamophilin on P-gp was investigated through drug efflux assay, ATPase ass...

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Autores principales: Yu-Ning Teng, Bo-Hau Huang, Shih-Ya Huang, I-Ting Wu, Tian-Shung Wu, Tsui-Er Lee, Chin-Chuan Hung
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
Materias:
ATP-binding cassette
Cancer multi-drug resistance
Cinnamophilin
Cinnamomum philippinense
Natural product
P-glycoprotein
Therapeutics. Pharmacology
RM1-950
Acceso en línea:https://doaj.org/article/8de39f178a3c42a8ad05755b13c86a09
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https://doaj.org/article/8de39f178a3c42a8ad05755b13c86a09

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