Extracellular zinc competitively inhibits manganese uptake and compromises oxidative stress management in Streptococcus pneumoniae.

Streptococcus pneumoniae requires manganese for colonization of the human host, but the underlying molecular basis for this requirement has not been elucidated. Recently, it was shown that zinc could compromise manganese uptake and that zinc levels increased during infection by S. pneumoniae in all...

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Auteurs principaux: Bart A Eijkelkamp, Jacqueline R Morey, Miranda P Ween, Cheryl-lynn Y Ong, Alastair G McEwan, James C Paton, Christopher A McDevitt
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2014
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Accès en ligne:https://doaj.org/article/8df264e3720c49de8a31fbe146abd13e
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