Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames

Cryptic translation of the 'non-coding' genome is increasingly recognised, however its biological significance remains unclear. Laumont et al.employ proteogenomic techniques to map the human immunoproteome, and find that approximately 10% of MHC class I-associated peptides are cryptic.

Guardado en:

Detalles Bibliográficos
Autores principales:	Céline M. Laumont, Tariq Daouda, Jean-Philippe Laverdure, Éric Bonneil, Olivier Caron-Lizotte, Marie-Pierre Hardy, Diana P. Granados, Chantal Durette, Sébastien Lemieux, Pierre Thibault, Claude Perreault
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8e030826a1744d55a142f5a4d3124d1e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8e030826a1744d55a142f5a4d3124d1e
record_format	dspace
spelling	oai:doaj.org-article:8e030826a1744d55a142f5a4d3124d1e2021-12-02T16:57:39ZGlobal proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames10.1038/ncomms102382041-1723https://doaj.org/article/8e030826a1744d55a142f5a4d3124d1e2016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10238https://doaj.org/toc/2041-1723Cryptic translation of the 'non-coding' genome is increasingly recognised, however its biological significance remains unclear. Laumont et al.employ proteogenomic techniques to map the human immunoproteome, and find that approximately 10% of MHC class I-associated peptides are cryptic.Céline M. LaumontTariq DaoudaJean-Philippe LaverdureÉric BonneilOlivier Caron-LizotteMarie-Pierre HardyDiana P. GranadosChantal DuretteSébastien LemieuxPierre ThibaultClaude PerreaultNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Céline M. Laumont Tariq Daouda Jean-Philippe Laverdure Éric Bonneil Olivier Caron-Lizotte Marie-Pierre Hardy Diana P. Granados Chantal Durette Sébastien Lemieux Pierre Thibault Claude Perreault Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames
description	Cryptic translation of the 'non-coding' genome is increasingly recognised, however its biological significance remains unclear. Laumont et al.employ proteogenomic techniques to map the human immunoproteome, and find that approximately 10% of MHC class I-associated peptides are cryptic.
format	article
author	Céline M. Laumont Tariq Daouda Jean-Philippe Laverdure Éric Bonneil Olivier Caron-Lizotte Marie-Pierre Hardy Diana P. Granados Chantal Durette Sébastien Lemieux Pierre Thibault Claude Perreault
author_facet	Céline M. Laumont Tariq Daouda Jean-Philippe Laverdure Éric Bonneil Olivier Caron-Lizotte Marie-Pierre Hardy Diana P. Granados Chantal Durette Sébastien Lemieux Pierre Thibault Claude Perreault
author_sort	Céline M. Laumont
title	Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames
title_short	Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames
title_full	Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames
title_fullStr	Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames
title_full_unstemmed	Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames
title_sort	global proteogenomic analysis of human mhc class i-associated peptides derived from non-canonical reading frames
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/8e030826a1744d55a142f5a4d3124d1e
work_keys_str_mv	AT celinemlaumont globalproteogenomicanalysisofhumanmhcclassiassociatedpeptidesderivedfromnoncanonicalreadingframes AT tariqdaouda globalproteogenomicanalysisofhumanmhcclassiassociatedpeptidesderivedfromnoncanonicalreadingframes AT jeanphilippelaverdure globalproteogenomicanalysisofhumanmhcclassiassociatedpeptidesderivedfromnoncanonicalreadingframes AT ericbonneil globalproteogenomicanalysisofhumanmhcclassiassociatedpeptidesderivedfromnoncanonicalreadingframes AT oliviercaronlizotte globalproteogenomicanalysisofhumanmhcclassiassociatedpeptidesderivedfromnoncanonicalreadingframes AT mariepierrehardy globalproteogenomicanalysisofhumanmhcclassiassociatedpeptidesderivedfromnoncanonicalreadingframes AT dianapgranados globalproteogenomicanalysisofhumanmhcclassiassociatedpeptidesderivedfromnoncanonicalreadingframes AT chantaldurette globalproteogenomicanalysisofhumanmhcclassiassociatedpeptidesderivedfromnoncanonicalreadingframes AT sebastienlemieux globalproteogenomicanalysisofhumanmhcclassiassociatedpeptidesderivedfromnoncanonicalreadingframes AT pierrethibault globalproteogenomicanalysisofhumanmhcclassiassociatedpeptidesderivedfromnoncanonicalreadingframes AT claudeperreault globalproteogenomicanalysisofhumanmhcclassiassociatedpeptidesderivedfromnoncanonicalreadingframes
_version_	1718382513034887168

Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames

Ejemplares similares