PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates

Shimizu et al. identify PLZF/ZBTB16 and its fusion proteins as pomalidomide-dependent neosubstrates of the cereblon E3 ligase. The authors also report that pomalidomide induces their degradation and thereby exerts its anti-cancer effect in leukemic cells expressing the fusion proteins.

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Autores principales:	Nobuyuki Shimizu, Tomoko Asatsuma-Okumura, Junichi Yamamoto, Yuki Yamaguchi, Hiroshi Handa, Takumi Ito
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8e042573d7f949a6bd3a74bcd451d1ff
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spelling	oai:doaj.org-article:8e042573d7f949a6bd3a74bcd451d1ff2021-11-14T12:12:17ZPLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates10.1038/s42003-021-02801-y2399-3642https://doaj.org/article/8e042573d7f949a6bd3a74bcd451d1ff2021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02801-yhttps://doaj.org/toc/2399-3642Shimizu et al. identify PLZF/ZBTB16 and its fusion proteins as pomalidomide-dependent neosubstrates of the cereblon E3 ligase. The authors also report that pomalidomide induces their degradation and thereby exerts its anti-cancer effect in leukemic cells expressing the fusion proteins.Nobuyuki ShimizuTomoko Asatsuma-OkumuraJunichi YamamotoYuki YamaguchiHiroshi HandaTakumi ItoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Nobuyuki Shimizu Tomoko Asatsuma-Okumura Junichi Yamamoto Yuki Yamaguchi Hiroshi Handa Takumi Ito PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates
description	Shimizu et al. identify PLZF/ZBTB16 and its fusion proteins as pomalidomide-dependent neosubstrates of the cereblon E3 ligase. The authors also report that pomalidomide induces their degradation and thereby exerts its anti-cancer effect in leukemic cells expressing the fusion proteins.
format	article
author	Nobuyuki Shimizu Tomoko Asatsuma-Okumura Junichi Yamamoto Yuki Yamaguchi Hiroshi Handa Takumi Ito
author_facet	Nobuyuki Shimizu Tomoko Asatsuma-Okumura Junichi Yamamoto Yuki Yamaguchi Hiroshi Handa Takumi Ito
author_sort	Nobuyuki Shimizu
title	PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates
title_short	PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates
title_full	PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates
title_fullStr	PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates
title_full_unstemmed	PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates
title_sort	plzf and its fusion proteins are pomalidomide-dependent crbn neosubstrates
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8e042573d7f949a6bd3a74bcd451d1ff
work_keys_str_mv	AT nobuyukishimizu plzfanditsfusionproteinsarepomalidomidedependentcrbnneosubstrates AT tomokoasatsumaokumura plzfanditsfusionproteinsarepomalidomidedependentcrbnneosubstrates AT junichiyamamoto plzfanditsfusionproteinsarepomalidomidedependentcrbnneosubstrates AT yukiyamaguchi plzfanditsfusionproteinsarepomalidomidedependentcrbnneosubstrates AT hiroshihanda plzfanditsfusionproteinsarepomalidomidedependentcrbnneosubstrates AT takumiito plzfanditsfusionproteinsarepomalidomidedependentcrbnneosubstrates
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PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates

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