PINK1 is selectively stabilized on impaired mitochondria to activate Parkin.
Loss-of-function mutations in PINK1 and Parkin cause parkinsonism in humans and mitochondrial dysfunction in model organisms. Parkin is selectively recruited from the cytosol to damaged mitochondria to trigger their autophagy. How Parkin recognizes damaged mitochondria, however, is unknown. Here, we...
Enregistré dans:
| Auteurs principaux: | , , , , , , , |
|---|---|
| Format: | article |
| Langue: | EN |
| Publié: |
Public Library of Science (PLoS)
2010
|
| Sujets: | |
| Accès en ligne: | https://doaj.org/article/8e127fc52b86486593b7ee294d8b508c |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|