Genome-wide transcriptional reorganization associated with senescence-to-immortality switch during human hepatocellular carcinogenesis.

Genome-wide transcriptional reorganization associated with senescence-to-immortality switch during human hepatocellular carcinogenesis.

Senescence is a permanent proliferation arrest in response to cell stress such as DNA damage. It contributes strongly to tissue aging and serves as a major barrier against tumor development. Most tumor cells are believed to bypass the senescence barrier (become "immortal") by inactivating...

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Main Authors: Gokhan Yildiz, Ayca Arslan-Ergul, Sevgi Bagislar, Ozlen Konu, Haluk Yuzugullu, Ozge Gursoy-Yuzugullu, Nuri Ozturk, Cigdem Ozen, Hilal Ozdag, Esra Erdal, Sedat Karademir, Ozgul Sagol, Dilsa Mizrak, Hakan Bozkaya, Hakki Gokhan Ilk, Ozlem Ilk, Biter Bilen, Rengul Cetin-Atalay, Nejat Akar, Mehmet Ozturk
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/8e1281cde73745e7a1c2cc9e38f3e9db
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https://doaj.org/article/8e1281cde73745e7a1c2cc9e38f3e9db

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