Evolution of AF6-RAS association and its implications in mixed-lineage leukemia

Evolution of AF6-RAS association and its implications in mixed-lineage leukemia

Several rearrangements of the MLL gene are associated with acute leukemia, including the fusion of MLL with a RAS effector protein, AF6. Here the authors show that the truncated AF6 can induce AF6-MLL dimerization and drive its oncogenic activity.

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Auteurs principaux: Matthew J. Smith, Elizabeth Ottoni, Noboru Ishiyama, Marilyn Goudreault, André Haman, Claus Meyer, Monika Tucholska, Genevieve Gasmi-Seabrook, Serena Menezes, Rob C. Laister, Mark D. Minden, Rolf Marschalek, Anne-Claude Gingras, Trang Hoang, Mitsuhiko Ikura
Format: article
Langue:EN
Publié: Nature Portfolio 2017
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/8e1f5d31a64445fb84962ab9b91f057b
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Internet

https://doaj.org/article/8e1f5d31a64445fb84962ab9b91f057b

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