Evolution of AF6-RAS association and its implications in mixed-lineage leukemia

Evolution of AF6-RAS association and its implications in mixed-lineage leukemia

Several rearrangements of the MLL gene are associated with acute leukemia, including the fusion of MLL with a RAS effector protein, AF6. Here the authors show that the truncated AF6 can induce AF6-MLL dimerization and drive its oncogenic activity.

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Autores principales: Matthew J. Smith, Elizabeth Ottoni, Noboru Ishiyama, Marilyn Goudreault, André Haman, Claus Meyer, Monika Tucholska, Genevieve Gasmi-Seabrook, Serena Menezes, Rob C. Laister, Mark D. Minden, Rolf Marschalek, Anne-Claude Gingras, Trang Hoang, Mitsuhiko Ikura
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/8e1f5d31a64445fb84962ab9b91f057b
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spelling oai:doaj.org-article:8e1f5d31a64445fb84962ab9b91f057b2021-12-02T15:38:41ZEvolution of AF6-RAS association and its implications in mixed-lineage leukemia10.1038/s41467-017-01326-52041-1723https://doaj.org/article/8e1f5d31a64445fb84962ab9b91f057b2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01326-5https://doaj.org/toc/2041-1723Several rearrangements of the MLL gene are associated with acute leukemia, including the fusion of MLL with a RAS effector protein, AF6. Here the authors show that the truncated AF6 can induce AF6-MLL dimerization and drive its oncogenic activity.Matthew J. SmithElizabeth OttoniNoboru IshiyamaMarilyn GoudreaultAndré HamanClaus MeyerMonika TucholskaGenevieve Gasmi-SeabrookSerena MenezesRob C. LaisterMark D. MindenRolf MarschalekAnne-Claude GingrasTrang HoangMitsuhiko IkuraNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Matthew J. Smith
Elizabeth Ottoni
Noboru Ishiyama
Marilyn Goudreault
André Haman
Claus Meyer
Monika Tucholska
Genevieve Gasmi-Seabrook
Serena Menezes
Rob C. Laister
Mark D. Minden
Rolf Marschalek
Anne-Claude Gingras
Trang Hoang
Mitsuhiko Ikura
Evolution of AF6-RAS association and its implications in mixed-lineage leukemia
description Several rearrangements of the MLL gene are associated with acute leukemia, including the fusion of MLL with a RAS effector protein, AF6. Here the authors show that the truncated AF6 can induce AF6-MLL dimerization and drive its oncogenic activity.
format article
author Matthew J. Smith
Elizabeth Ottoni
Noboru Ishiyama
Marilyn Goudreault
André Haman
Claus Meyer
Monika Tucholska
Genevieve Gasmi-Seabrook
Serena Menezes
Rob C. Laister
Mark D. Minden
Rolf Marschalek
Anne-Claude Gingras
Trang Hoang
Mitsuhiko Ikura
author_facet Matthew J. Smith
Elizabeth Ottoni
Noboru Ishiyama
Marilyn Goudreault
André Haman
Claus Meyer
Monika Tucholska
Genevieve Gasmi-Seabrook
Serena Menezes
Rob C. Laister
Mark D. Minden
Rolf Marschalek
Anne-Claude Gingras
Trang Hoang
Mitsuhiko Ikura
author_sort Matthew J. Smith
title Evolution of AF6-RAS association and its implications in mixed-lineage leukemia
title_short Evolution of AF6-RAS association and its implications in mixed-lineage leukemia
title_full Evolution of AF6-RAS association and its implications in mixed-lineage leukemia
title_fullStr Evolution of AF6-RAS association and its implications in mixed-lineage leukemia
title_full_unstemmed Evolution of AF6-RAS association and its implications in mixed-lineage leukemia
title_sort evolution of af6-ras association and its implications in mixed-lineage leukemia
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/8e1f5d31a64445fb84962ab9b91f057b
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