Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan
Understanding the genetic influences on human aging requires a large number of subjects for a study of sufficient power. Here, Jim Wilson and colleagues use information on parental ages at death to show that common variants near the genes for apolipoprotein E and nicotinic acetylcholine receptor sub...
Saved in:
Main Authors: | Peter K. Joshi, Krista Fischer, Katharina E. Schraut, Harry Campbell, Tõnu Esko, James F. Wilson |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2016
|
Subjects: | |
Online Access: | https://doaj.org/article/8e27ea7a9faf4fdf809be7c157f8f6a1 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Massive withdrawal symptoms and affective vulnerability are associated with variants of the CHRNA4 gene in a subgroup of smokers.
by: Judit Lazary, et al.
Published: (2014) -
Genetic Modifiers of Oral Nicotine Consumption in Chrna5 Null Mutant Mice
by: Erin Meyers, et al.
Published: (2021) -
Microglial transcription profiles in mouse and human are driven by APOE4 and sex
by: V. Alexandra Moser, et al.
Published: (2021) -
Exercising <i>D. melanogaster</i> Modulates the Mitochondrial Proteome and Physiology. The Effect on Lifespan Depends upon Age and Sex
by: Brad Ebanks, et al.
Published: (2021) -
Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome
by: Matthias Arnold, et al.
Published: (2020)