Vaccination to prevent T cell subversion can protect against persistent hepacivirus infection

Development of a HCV vaccine is hampered by a lack of appropriate small animal models. Here, Hartlage et al. describe a rat model of hepacivirus persistence and show that persistence can be prevented by vaccination with viral non-structural proteins.

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Autores principales:	Alex S. Hartlage, Satyapramod Murthy, Arvind Kumar, Sheetal Trivedi, Piyush Dravid, Himanshu Sharma, Christopher M. Walker, Amit Kapoor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8e3f05a0172441aea2e16eff245c50b0
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spelling	oai:doaj.org-article:8e3f05a0172441aea2e16eff245c50b02021-12-02T15:35:34ZVaccination to prevent T cell subversion can protect against persistent hepacivirus infection10.1038/s41467-019-09105-02041-1723https://doaj.org/article/8e3f05a0172441aea2e16eff245c50b02019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09105-0https://doaj.org/toc/2041-1723Development of a HCV vaccine is hampered by a lack of appropriate small animal models. Here, Hartlage et al. describe a rat model of hepacivirus persistence and show that persistence can be prevented by vaccination with viral non-structural proteins.Alex S. HartlageSatyapramod MurthyArvind KumarSheetal TrivediPiyush DravidHimanshu SharmaChristopher M. WalkerAmit KapoorNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alex S. Hartlage Satyapramod Murthy Arvind Kumar Sheetal Trivedi Piyush Dravid Himanshu Sharma Christopher M. Walker Amit Kapoor Vaccination to prevent T cell subversion can protect against persistent hepacivirus infection
description	Development of a HCV vaccine is hampered by a lack of appropriate small animal models. Here, Hartlage et al. describe a rat model of hepacivirus persistence and show that persistence can be prevented by vaccination with viral non-structural proteins.
format	article
author	Alex S. Hartlage Satyapramod Murthy Arvind Kumar Sheetal Trivedi Piyush Dravid Himanshu Sharma Christopher M. Walker Amit Kapoor
author_facet	Alex S. Hartlage Satyapramod Murthy Arvind Kumar Sheetal Trivedi Piyush Dravid Himanshu Sharma Christopher M. Walker Amit Kapoor
author_sort	Alex S. Hartlage
title	Vaccination to prevent T cell subversion can protect against persistent hepacivirus infection
title_short	Vaccination to prevent T cell subversion can protect against persistent hepacivirus infection
title_full	Vaccination to prevent T cell subversion can protect against persistent hepacivirus infection
title_fullStr	Vaccination to prevent T cell subversion can protect against persistent hepacivirus infection
title_full_unstemmed	Vaccination to prevent T cell subversion can protect against persistent hepacivirus infection
title_sort	vaccination to prevent t cell subversion can protect against persistent hepacivirus infection
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8e3f05a0172441aea2e16eff245c50b0
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Vaccination to prevent T cell subversion can protect against persistent hepacivirus infection

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