Molecular insights into the endoperoxide formation by Fe(II)/α-KG-dependent oxygenase NvfI

Many endoperoxide-containing natural products have been isolated, but the biosynthesis of the endoperoxides remains unclear. Here, the authors report the structural and functional analysis of the NvfI endoperoxidase that catalyzes the formation of fumigatonoid A in the biosynthesis of novofumigatoni...

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Autores principales:	Takahiro Mori, Rui Zhai, Richiro Ushimaru, Yudai Matsuda, Ikuro Abe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8ecfd9aaea274ad3882afbb439bc7ed7
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spelling	oai:doaj.org-article:8ecfd9aaea274ad3882afbb439bc7ed72021-12-02T16:18:00ZMolecular insights into the endoperoxide formation by Fe(II)/α-KG-dependent oxygenase NvfI10.1038/s41467-021-24685-62041-1723https://doaj.org/article/8ecfd9aaea274ad3882afbb439bc7ed72021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24685-6https://doaj.org/toc/2041-1723Many endoperoxide-containing natural products have been isolated, but the biosynthesis of the endoperoxides remains unclear. Here, the authors report the structural and functional analysis of the NvfI endoperoxidase that catalyzes the formation of fumigatonoid A in the biosynthesis of novofumigatonin, and show that it does not employ tyrosyl radical in the reaction.Takahiro MoriRui ZhaiRichiro UshimaruYudai MatsudaIkuro AbeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Takahiro Mori Rui Zhai Richiro Ushimaru Yudai Matsuda Ikuro Abe Molecular insights into the endoperoxide formation by Fe(II)/α-KG-dependent oxygenase NvfI
description	Many endoperoxide-containing natural products have been isolated, but the biosynthesis of the endoperoxides remains unclear. Here, the authors report the structural and functional analysis of the NvfI endoperoxidase that catalyzes the formation of fumigatonoid A in the biosynthesis of novofumigatonin, and show that it does not employ tyrosyl radical in the reaction.
format	article
author	Takahiro Mori Rui Zhai Richiro Ushimaru Yudai Matsuda Ikuro Abe
author_facet	Takahiro Mori Rui Zhai Richiro Ushimaru Yudai Matsuda Ikuro Abe
author_sort	Takahiro Mori
title	Molecular insights into the endoperoxide formation by Fe(II)/α-KG-dependent oxygenase NvfI
title_short	Molecular insights into the endoperoxide formation by Fe(II)/α-KG-dependent oxygenase NvfI
title_full	Molecular insights into the endoperoxide formation by Fe(II)/α-KG-dependent oxygenase NvfI
title_fullStr	Molecular insights into the endoperoxide formation by Fe(II)/α-KG-dependent oxygenase NvfI
title_full_unstemmed	Molecular insights into the endoperoxide formation by Fe(II)/α-KG-dependent oxygenase NvfI
title_sort	molecular insights into the endoperoxide formation by fe(ii)/α-kg-dependent oxygenase nvfi
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8ecfd9aaea274ad3882afbb439bc7ed7
work_keys_str_mv	AT takahiromori molecularinsightsintotheendoperoxideformationbyfeiiakgdependentoxygenasenvfi AT ruizhai molecularinsightsintotheendoperoxideformationbyfeiiakgdependentoxygenasenvfi AT richiroushimaru molecularinsightsintotheendoperoxideformationbyfeiiakgdependentoxygenasenvfi AT yudaimatsuda molecularinsightsintotheendoperoxideformationbyfeiiakgdependentoxygenasenvfi AT ikuroabe molecularinsightsintotheendoperoxideformationbyfeiiakgdependentoxygenasenvfi
_version_	1718384243446382592

Molecular insights into the endoperoxide formation by Fe(II)/α-KG-dependent oxygenase NvfI

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