Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions.

<h4>Background</h4>Prion-based diseases are incurable transmissible neurodegenerative disorders affecting animals and humans.<h4>Methodology/principal findings</h4>Here we report the discovery of the in vivo antiprion activity of Guanabenz (GA), an agonist of alpha2-adrenergi...

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Main Authors: Déborah Tribouillard-Tanvier, Vincent Béringue, Nathalie Desban, Fabienne Gug, Stéphane Bach, Cécile Voisset, Hervé Galons, Hubert Laude, Didier Vilette, Marc Blondel
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2008
Subjects:
R
Q
Online Access:https://doaj.org/article/8eefe3241ca1455293c7d0b0209d1fe1
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