Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells
A vaccine to generate durable HIV broadly neutralizing antibodies (bnAb) from engineered B cells holds promise as an HIV functional cure. Here, the authors show that CRISPR/Cas-modified B cells expressing bnAbs as functional antigen receptors can be immunized to generate long-lived, germinal centre...
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Nature Portfolio
2020
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oai:doaj.org-article:8f0e41a577a24e6390766e0efaf6153c2021-12-02T15:39:09ZVaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells10.1038/s41467-020-19650-82041-1723https://doaj.org/article/8f0e41a577a24e6390766e0efaf6153c2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19650-8https://doaj.org/toc/2041-1723A vaccine to generate durable HIV broadly neutralizing antibodies (bnAb) from engineered B cells holds promise as an HIV functional cure. Here, the authors show that CRISPR/Cas-modified B cells expressing bnAbs as functional antigen receptors can be immunized to generate long-lived, germinal centre matured bnAb memory and plasma cells in mice.Deli HuangJenny Tuyet TranAlex OlsonThomas VollbrechtMary TenutaMariia V. GurylevaRoberta P. FullerTorben SchiffnerJustin R. AbadejosLauren CouvretteTanya R. BlaneKaren SayeWenjuan LiElise LandaisAlicia Gonzalez-MartinWilliam SchiefBen MurrellDennis R. BurtonDavid NemazeeJames E. VossNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Deli Huang Jenny Tuyet Tran Alex Olson Thomas Vollbrecht Mary Tenuta Mariia V. Guryleva Roberta P. Fuller Torben Schiffner Justin R. Abadejos Lauren Couvrette Tanya R. Blane Karen Saye Wenjuan Li Elise Landais Alicia Gonzalez-Martin William Schief Ben Murrell Dennis R. Burton David Nemazee James E. Voss Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells |
| description |
A vaccine to generate durable HIV broadly neutralizing antibodies (bnAb) from engineered B cells holds promise as an HIV functional cure. Here, the authors show that CRISPR/Cas-modified B cells expressing bnAbs as functional antigen receptors can be immunized to generate long-lived, germinal centre matured bnAb memory and plasma cells in mice. |
| format |
article |
| author |
Deli Huang Jenny Tuyet Tran Alex Olson Thomas Vollbrecht Mary Tenuta Mariia V. Guryleva Roberta P. Fuller Torben Schiffner Justin R. Abadejos Lauren Couvrette Tanya R. Blane Karen Saye Wenjuan Li Elise Landais Alicia Gonzalez-Martin William Schief Ben Murrell Dennis R. Burton David Nemazee James E. Voss |
| author_facet |
Deli Huang Jenny Tuyet Tran Alex Olson Thomas Vollbrecht Mary Tenuta Mariia V. Guryleva Roberta P. Fuller Torben Schiffner Justin R. Abadejos Lauren Couvrette Tanya R. Blane Karen Saye Wenjuan Li Elise Landais Alicia Gonzalez-Martin William Schief Ben Murrell Dennis R. Burton David Nemazee James E. Voss |
| author_sort |
Deli Huang |
| title |
Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells |
| title_short |
Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells |
| title_full |
Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells |
| title_fullStr |
Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells |
| title_full_unstemmed |
Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells |
| title_sort |
vaccine elicitation of hiv broadly neutralizing antibodies from engineered b cells |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/8f0e41a577a24e6390766e0efaf6153c |
| work_keys_str_mv |
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1718386002521751552 |