Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma

Erastin, the ferroptosis activator, binds to voltage gated ion channels CDAC2 and VDCA3 but treatment with erastin can result in the degradation of the channels. Here, the authors show that Nedd4 is induced following erastin treatment, which leads to the ubiquitination and subsequent degradation of...

Full description

Saved in:
Bibliographic Details
Main Authors: Yongfei Yang, Meiying Luo, Kexin Zhang, Jun Zhang, Tongtong Gao, Douglas O’ Connell, Fengping Yao, Changwen Mu, Bingyu Cai, Yuxue Shang, Wei Chen
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Q
Online Access:https://doaj.org/article/8f3cb0fc75d84affa78fca2ae1a5777c
Tags: Add Tag
No Tags, Be the first to tag this record!