Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma

Erastin, the ferroptosis activator, binds to voltage gated ion channels CDAC2 and VDCA3 but treatment with erastin can result in the degradation of the channels. Here, the authors show that Nedd4 is induced following erastin treatment, which leads to the ubiquitination and subsequent degradation of...

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Autores principales:	Yongfei Yang, Meiying Luo, Kexin Zhang, Jun Zhang, Tongtong Gao, Douglas O’ Connell, Fengping Yao, Changwen Mu, Bingyu Cai, Yuxue Shang, Wei Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8f3cb0fc75d84affa78fca2ae1a5777c
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spelling	oai:doaj.org-article:8f3cb0fc75d84affa78fca2ae1a5777c2021-12-02T14:40:54ZNedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma10.1038/s41467-020-14324-x2041-1723https://doaj.org/article/8f3cb0fc75d84affa78fca2ae1a5777c2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14324-xhttps://doaj.org/toc/2041-1723Erastin, the ferroptosis activator, binds to voltage gated ion channels CDAC2 and VDCA3 but treatment with erastin can result in the degradation of the channels. Here, the authors show that Nedd4 is induced following erastin treatment, which leads to the ubiquitination and subsequent degradation of the channels.Yongfei YangMeiying LuoKexin ZhangJun ZhangTongtong GaoDouglas O’ ConnellFengping YaoChangwen MuBingyu CaiYuxue ShangWei ChenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yongfei Yang Meiying Luo Kexin Zhang Jun Zhang Tongtong Gao Douglas O’ Connell Fengping Yao Changwen Mu Bingyu Cai Yuxue Shang Wei Chen Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma
description	Erastin, the ferroptosis activator, binds to voltage gated ion channels CDAC2 and VDCA3 but treatment with erastin can result in the degradation of the channels. Here, the authors show that Nedd4 is induced following erastin treatment, which leads to the ubiquitination and subsequent degradation of the channels.
format	article
author	Yongfei Yang Meiying Luo Kexin Zhang Jun Zhang Tongtong Gao Douglas O’ Connell Fengping Yao Changwen Mu Bingyu Cai Yuxue Shang Wei Chen
author_facet	Yongfei Yang Meiying Luo Kexin Zhang Jun Zhang Tongtong Gao Douglas O’ Connell Fengping Yao Changwen Mu Bingyu Cai Yuxue Shang Wei Chen
author_sort	Yongfei Yang
title	Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma
title_short	Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma
title_full	Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma
title_fullStr	Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma
title_full_unstemmed	Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma
title_sort	nedd4 ubiquitylates vdac2/3 to suppress erastin-induced ferroptosis in melanoma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8f3cb0fc75d84affa78fca2ae1a5777c
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Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma

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