A molecular mechanism for eflornithine resistance in African trypanosomes.

Human African trypanosomiasis, endemic to sub-Saharan Africa, is invariably fatal if untreated. Its causative agent is the protozoan parasite Trypanosoma brucei. Eflornithine is used as a first line treatment for human African trypanosomiasis, but there is a risk that resistance could thwart its use...

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Main Authors: Isabel M Vincent, Darren Creek, David G Watson, Mohammed A Kamleh, Debra J Woods, Pui Ee Wong, Richard J S Burchmore, Michael P Barrett
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2010
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Online Access:https://doaj.org/article/8f3e95995c734e62a7d35c0a2ca33da7
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